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- Title
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review.
- Authors
Wikan, Vårin Eiriksdatter; Tøndel, Birgitte Gladsø; Morelli, Vânia Maris; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne
- Abstract
(1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency department with suspected acute PE. (2) Methods: Medline and Embase databases were searched from 1995 to the present. The study selection process, data extraction, and risk of bias assessment were conducted by two reviewers. Eligibility criteria accepted all blood biomarkers except D-dimer, and CTPA was used as the reference standard. Qualitative data synthesis was performed. (3) Results: Of the 8448 identified records, only 6 were included. Eight blood biomarkers were identified, of which, three were investigated in two separate studies. Red distribution width and mean platelet volume were reported to have a specificity of ≥ 90% in one study, although these findings were not confirmed by other studies. The majority of the studies contained a high risk of selection bias. (4) Conclusions: The modest findings and the uncertain validity of the included studies suggest that none of the biomarkers identified in this systematic review have the potential to improve the current diagnostic algorithm for acute PE by reducing the overuse of CTPA.
- Subjects
PULMONARY embolism; MEAN platelet volume; BIOMARKERS; DATA extraction; BLOOD testing
- Publication
Diagnostics (2075-4418), 2023, Vol 13, Issue 13, p2301
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics13132301