We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Different morphology, stage and treatment affect immune cell infiltration and long-term outcome in patients with non-small-cell lung carcinoma.
- Authors
da Costa Souza, Paola; Parra, Edwin Roger; Junqueira Atanazio, Marcelo; da Silva, Osmar Bianchi; Sousa Noleto, Gustavo; Muxfeldt Ab'Saber, Alexandre; de Morais Fernezlian, Sandra; Takagaki, Tereza; Capelozzi, Vera Luiza
- Abstract
Aims: Development of effective immune-based therapies for patients with non-small-cell lung carcinoma (NSCLC) depends on an accurate characterization of complex interactions that occur between immune cells and the tumour environment. Methods and results: Innate and adaptive immune responses were evaluated in relation to prognosis in 65 patients with surgically excised NSCLC. Immunohistochemistry and morphometry were used to determine the abundance and distribution of immune cells. We found low numbers of immune cells and levels of cytokines in the tumour environment when compared with surrounding parenchyma. Smoking was associated inversely with the adaptive immune response and directly with innate immunity. We observed a prominent adaptive immune response in squamous cell carcinomas (SCC) but greater innate immune responses in adenocarcinomas and large cell carcinomas. Cox model analysis showed a low risk of death for smoking <41 packs/year, N0 tambour stage, squamous carcinoma, CD4+ > 16.81% and macrophages/monocytes >4.5%. Collectively, the data indicate that in NSCLC there is not a substantive local immune cell infiltrate within the tumour. Conclusion: Although immune cell infiltration is limited in NSCLC it appears to have an impact on prognosis and this may be of relevance for new immunotherapeutic approaches.
- Subjects
CYTOKINES; CELLULAR immunity; IMMUNE response; LUNG cancer; CELLS; CANCER patients; MORPHOLOGY
- Publication
Histopathology, 2012, Vol 61, Issue 4, p587
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2012.04318.x