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- Title
Disease Progression of Hospitalized Elderly Patients with Omicron BA.2 Treated with Molnupiravir.
- Authors
Liu, Yayun; Ge, Lingling; Fan, Shiyong; Xu, Aijing; Wang, Xinyu; Dong, Xu; Xu, Mingxiao; Fan, Wenhan; Zhong, Wu; Liang, Xuesong
- Abstract
Introduction: The efficacy of molnupiravir (MLN) on Omicron sublineages is limited. We investigated the effectiveness of MLN in older adults diagnosed with Omicron BA.2. Methods: Data of elderly COVID-19 patients (over 60 years) admitted to Chinghai Hospital (Shanghai, China) from 26 March to 31 May 2022 were reviewed. Study outcomes were a composite of undetectable viral load (VL) and disease progression [all-cause mortality, initiation of oxygen supply through high-flow device or invasive mechanical ventilation (IMV), or intensive care unit (ICU) admission] and their individual outcomes. Results: A total of 42 elderly patients were enrolled: 26 of them received MLN, 17 (40.5%) were males, the median age was 84 years, and 12 were fully vaccinated (31.0%). Among these elderly COVID-19 patients, five (11.90%) experienced obvious dyspnea or were transferred to ICU [three MLN users (11.5%) versus two non-MLN users (12.5%)]. Compared with no MLN use, MLN use was associated with rapid undetectable VL. At day 10, MLN users achieved significantly greater undetectable VL than non-MLN users. Adjusted analysis showed that elderly patients who received MLN were 7.584 times more likely to achieve undetectable VL at day 10 than non-MLN users. Overall, elderly patients experienced a median hospital stay of 13 days. Compared with patients receiving standard care (SC), the median hospital stay of MLN users was reduced by 2.5 days. Conclusion: Early initiation of MLN in elderly COVID-19 was associated with fast undetectable VL and short hospital stay.
- Subjects
OLDER patients; SARS-CoV-2 Omicron variant; MOLNUPIRAVIR; HOSPITAL patients; DISEASE progression; NASAL cannula
- Publication
Infectious Diseases & Therapy, 2022, Vol 11, Issue 6, p2241
- ISSN
2193-8229
- Publication type
Article
- DOI
10.1007/s40121-022-00716-7