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- Title
Special Licorice Extracts Containing Lowered Glycyrrhizin and Enhanced Licochalcone A Prevented Helicobacter pylori-Initiated, Salt Diet-Promoted Gastric Tumorigenesis.
- Authors
Park, Jong‐Min; Park, Sang‐Ho; Hong, Kyung‐Sook; Han, Young‐Min; Jang, Sang‐Ho; Kim, Eun‐Hee; Hahm, Ki‐Baik
- Abstract
Objective In spite of cytoprotective and anti-inflammatory actions, conventional licorice extracts (c-lico) were limitedly used due to serious side effects of glycyrrhizin. As our group had successfully isolated special licorice extracts (s-lico) lowering troublesome glycyrrhizin, but increasing licochalcone A, we have compared anti-inflammatory, antioxidative, and cytoprotective actions of s-lico and c-lico against either in vitro or in vivo Helicobacter pylori infection. Methods RT- PCR and Western blot were performed to check anti-inflammatory action and electron spin resonance ( ESR) and DCFDA spectroscopy to check antioxidative action. s-lico or c-lico was pretreated 1 hours before H. pylori infection on AGS cells. Interleukin-10 deficient mice inoculated H. pylori and followed with high salt containing pallet diets to produce H. pylori-associated chronic atrophic gastritis and gastric tumors, during which s-lico or c-lico-containing pellet diets were administered up to 24 weeks. Results s-lico had fabulous efficacy on scavenging ROS which was further confirmed by DCFDA study and ESR measurement. The expressions of COX-2, iNOS, VEGF, and IL-8 were increased after H. pylori infection, of which levels were significantly decreased with s-lico in a dose-dependent manner. s-lico significantly ameliorated hypoxia-induced or H. pylori-induced angiogenic activities. s-lico significantly ameliorated H. pylori-induced gastric damages as well as gastritis. Our animal model showed significant development of gastric tumors including adenoma and dysplasia relevant to H. pylori infection, and s-lico administration significantly attenuated incidence of H. pylori-induced gastric tumorigenesis. Conclusions Special licorice extracts can be anticipating substance afforded significant attenuation of either H. pylori-induced gastritis or tumorigenesis based on potent antioxidative, anti-inflammatory, and antimutagenic actions.
- Subjects
LICORICE (Plant); HELICOBACTER pylori; LICORICE products; GASTROENTERITIS treatment; HELICOBACTER diseases
- Publication
Helicobacter, 2014, Vol 19, Issue 3, p221
- ISSN
1083-4389
- Publication type
Article
- DOI
10.1111/hel.12121