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- Title
An In Vitro Investigation of Cytotoxic Effects of InP/Zns Quantum Dots with Different Surface Chemistries.
- Authors
Ayupova, Deanna; Dobhal, Garima; Laufersky, Geoffry; Nann, Thomas; Goreham, Renee V.
- Abstract
Indium phosphide quantum dots (QDs) passivated with zinc sulphide in a core/shell architecture (InP/ZnS) with different surface chemistries were introduced to RAW 264.7 murine "macrophage-like" cells to understand their potential toxicities. The InP/ZnS quantum dots were conjugated with an oligonucleotide, a carboxylic acid, or an amino-polyethylene glycol ligand, and cell viability and cell proliferation were investigated via a metabolic assay. Membrane integrity was measured through the production of lactate dehydrogenase. Fluorescence microscopy showed cellular uptake. All quantum dots exhibited cytotoxic behaviour less than that observed from cadmium- or lead-based quantum dots; however, this behaviour was sensitive to the ligands used. In particular, the amino-polyethylene glycol conjugated quantum dots proved to possess the highest cytotoxicity examined here. This provides quantitative evidence that aqueous InP/ZnS quantum dots can offer a safer alternative for bioimaging or in therapeutic applications.
- Subjects
QUANTUM dots; CYTOTOXINS; SURFACE chemistry; IN vitro toxicity testing; INDIUM phosphide; ZINC sulfide; FLUORESCENCE microscopy
- Publication
Nanomaterials (2079-4991), 2019, Vol 9, Issue 2, p135
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano9020135