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- Title
1-(2,4-Dihydroxyphenyl)-1-ethanone Hydrazone Derivatives as Notable Butyrylcholinesterase Inhibitors.
- Authors
Abbasi, Muhammad Athar; Niazi, Sikander Khan; Aziz-Ur-Rehman; Siddiqui, Sabahat Zahra; Hussain, Ghulam; Rasool, Shahid; Ashraf, Muhammad; Rahman, Jamil; Khan, Khalid Mohammed
- Abstract
Azomethine group of Schiff bases is known to express valuable biological activities. 1- (2,4-Dihydroxyphenyl)-1-ethanone N'-substituted hydrazone derivatives, 4a-s, were synthesized in multistep. The starting material 2,4-dihydroxyacetophenone (1) was stirred with hydrated hydrazine to yield 1-(2,4-dihydroxyphenyl)-1-ethanone hydrazone (2) which was further reacted with (un)substituted benzaldehydes, 3a-s, to acquire the target molecules, 4a-s. Moreover, the synthesized derivatives 4a-s was characterized via IR, EI-MS, 1H-NMR and 13C-NMR spectral techniques. Most of the compounds were found to be valuable inhibitors of butyrylcholinesterase enzyme.
- Subjects
BUTYRYLCHOLINESTERASE; SCHIFF bases; HYDROXYACETOPHENONES; CHEMISTRY education; HYDRAZINE
- Publication
Journal of the Chemical Society of Pakistan, 2016, Vol 38, Issue 1, p106
- ISSN
0253-5106
- Publication type
Article