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- Title
Extracellular vesicles in kidney development and pediatric kidney diseases.
- Authors
Ergunay, Tunahan; Collino, Federica; Bianchi, Gaia; Sedrakyan, Sargis; Perin, Laura; Bussolati, Benedetta
- Abstract
Extracellular vesicles (EVs) are membranous cargo particles that mediate intercellular communication. They are heterogeneous in size and mechanism of release, and found in all biological fluids. Since EV content is in relation to the originating cell type and to its physiopathological conditions, EVs are under study to understand organ physiology and pathology. In addition, EV surface cargo, or corona, can be influenced by the microenvironment, leading to the concept that EV-associated molecules can represent useful biomarkers for diseases. Recent studies also focus on the use of natural, engineered, or synthetic EVs for therapeutic purposes. This review highlights the role of EVs in kidney development, pediatric kidney diseases, including inherited disorders, and kidney transplantation. Although few studies exist, they have promising results and may guide researchers in this field. Main limitations, including the influence of age on EV analyses, are also discussed.
- Subjects
INFLAMMATION prevention; KIDNEY physiology; EXTRACELLULAR vesicles; KIDNEY transplantation; KIDNEY failure; PROGRAMMED death-ligand 1; MESENCHYMAL stem cells; FOCAL segmental glomerulosclerosis; MESSENGER RNA; NEPHROTIC syndrome; FIBROSIS; BIOMEDICAL engineering; KIDNEY diseases; BIOMARKERS; GLOMERULAR filtration rate; CHILDREN
- Publication
Pediatric Nephrology, 2024, Vol 39, Issue 7, p1967
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-023-06165-9