We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy of a Combination of Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse on Insomnia: A Triple-Blind, Randomized Placebo-Controlled Clinical Trial.
- Authors
Ranjbar, Maryam; Salehi, Alireza; Rezaeizadeh, Hossein; Zarshenas, Mohammad M.; Sadeghniiat-Haghighi, Khosro; Mirabzadeh, Mehran; Firoozabadi, Ali
- Abstract
Background: Insomnia is a prevalent sleep disorder that has not been well managed thus far. There are numerous medicaments for treatment of insomnia, but they have undesirable side effects that make herbal medicine a more viable option. Objectives: The effectiveness of a combination of Melissa officinalis L. (dry powder) and Nepeta menthoides Boiss. & Buhse (freeze-dried aqueous extract) on insomnia was evaluated. Design and Setting: Insomniacs who met the entry criteria participated in a triple-blind randomized placebo-controlled clinical trial at the Persian Medicine (PM) clinic in Tehran. Interventions: The subjects received either 1000 mg of M. officinalis plus 400 mg N. menthoides or a placebo nightly for four weeks in accordance with prescriptions from the pharmaceutical manuscripts on PM and the results of previous studies. Outcome measures: The Pittsburgh Sleep Quality Index (PSQI), sleep diary, and Insomnia Severity Index (ISI) were used for assessment of insomnia. Results: Comparison of the treatment and placebo groups showed a significant decrease in the mean difference of ISI (4.97 ± 4.69 vs. 1.60 ± 3.70; p =; 0.002) and total PSQI (4.14 ± 3.69 vs. 1.42 ± 2.81; p = 0.001) scores in the treatment group. A significant increase was also observed in total sleep time of treatment group (p < 0.001) based on the sleep diary. Conclusions: A combination of M. officinalis and N. menthoides Boiss. & Buhse could be an alternative sleep improvement therapy.
- Subjects
IRAN; THERAPEUTIC use of plant extracts; ACADEMIC medical centers; ANALYSIS of variance; BACTERIAL growth; COMBINATION drug therapy; CHI-squared test; COMPARATIVE studies; DOSAGE forms of drugs; FREEZE-drying; INSOMNIA; MICROBIOLOGICAL techniques; PLACEBOS; POWDERS; QUESTIONNAIRES; RESEARCH funding; SCALE analysis (Psychology); STATISTICAL hypothesis testing; T-test (Statistics); LEMON balm; PLANT extracts; SAMPLE size (Statistics); PILOT projects; RANDOMIZED controlled trials; TREATMENT effectiveness; REPEATED measures design; BLIND experiment; DATA analysis software; DESCRIPTIVE statistics; FRIEDMAN test (Statistics); THERAPEUTICS
- Publication
Journal of Alternative & Complementary Medicine, 2018, Vol 24, Issue 12, p1197
- ISSN
1075-5535
- Publication type
Article
- DOI
10.1089/acm.2017.0153