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- Title
Concordance between <sup>99m</sup>Tc-ECD SPECT and <sup>18</sup>F-FDG PET interpretations in patients with cognitive disorders diagnosed according to NIA-AA criteria.
- Authors
Ito, Kimiteru; Shimano, Yasumasa; Imabayashi, Etsuko; Nakata, Yasuhiro; Omachi, Yoshie; Sato, Noriko; Arima, Kunimasa; Matsuda, Hiroshi
- Abstract
Objectives The purpose of this study was to clarify the concordance of diagnostic abilities and interobserver agreement between 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and brain perfusion single photon-emission computed tomography (SPECT) in patients with Alzheimer's disease (AD) who were diagnosed according to the research criteria of the National Institute of Aging-Alzheimer's Association Workshop. Methods Fifty-five patients with 'AD and mild cognitive impairment (MCI)' ( n = 40) and 'non-AD' ( n = 15) were evaluated with 18F-FDG PET and 99mTc-ethyl cysteinate dimer (ECD) SPECT during an 8-week period. Three radiologists independently graded the regional uptake in the frontal, temporal, parietal, and occipital lobes as well as the precuneus/posterior cingulate cortex in both images. Kappa values were used to determine the interobserver reliability regarding regional uptake. Results The regions with better interobserver reliability between 18F-FDG PET and 99mTc-ECD SPECT were the frontal, parietal, and temporal lobes. The 99mTc-ECD SPECT agreement in the occipital lobes was not significant. The frontal, temporal, and parietal lobes showed good correlations between 18F-FDG PET and 99mTc-ECD SPECT in the degree of uptake, but the occipital lobe and precuneus/posterior cingulate cortex did not show good correlations. The diagnostic accuracy rates of 'AD and MCI' ranged from 60% to 70% in both of the techniques. Conclusions The degree of uptake on 18F-FDG PET and 99mTc-ECD SPECT showed significant correlations in the frontal, temporal, and parietal lobes. The diagnostic abilities of 18F-FDG PET and 99mTc-ECD SPECT for 'AD and MCI,' when diagnosed according to the National Institute of Aging-Alzheimer's Association Workshop criteria, were nearly identical. Copyright © 2014 John Wiley & Sons, Ltd.
- Subjects
POSITRON emission tomography; COMPUTED tomography; MILD cognitive impairment; DIAGNOSIS; COGNITION disorders research
- Publication
International Journal of Geriatric Psychiatry, 2014, Vol 29, Issue 10, p1079
- ISSN
0885-6230
- Publication type
Article
- DOI
10.1002/gps.4102