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- Title
GLMN variants cause skin hyperpigmentation: a promising potential therapeutic target.
- Authors
Cao, Qiaoyu; Li, Ming
- Abstract
A recent study published in the British Journal of Dermatology has identified loss-of-function variants in the GLMN gene as a cause of generalized skin hyperpigmentation. The study used whole-exome and Sanger sequencing to identify these genetic variants in five unrelated families with autosomal-dominant generalized skin hyperpigmentation. The discovery of these variants expands our understanding of the genetic basis of skin hyperpigmentation disorders and opens up new possibilities for targeted therapies. However, the study also highlights the complexity of genetic interactions and suggests that additional factors may influence the manifestation of the disease. Further research is needed to elucidate these factors and their contributions to the disease.
- Subjects
HYPERPIGMENTATION; MELANINS; MET receptor; MICROPHTHALMIA-associated transcription factor
- Publication
British Journal of Dermatology, 2024, Vol 191, Issue 1, p11
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1093/bjd/ljae149