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- Title
Ex vivo microRNA and gene expression profiling of human Tr1‐like cells suggests a role for miR‐92a and ‐125a in the regulation of EOMES and IL‐10R.
- Authors
De Simone, Marco; Chirichella, Michele; Emming, Stefan; Mazzara, Saveria; Ranzani, Valeria; Gruarin, Paola; Moschetti, Giorgia; Pulvirenti, Nadia; Maglie, Stefano; Vasco, Chiara; Crosti, Maria Cristina; Rossetti, Grazisa; Pagani, Massimiliano; Abrignani, Sergio; Monticelli, Silvia; Geginat, Jens
- Abstract
Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R Tr1-like cells expressed higher levels of GZMK as compared to Th1 SB CM sb and CTL, and of IL-10R as compared to Th1-cells. In conclusion, by performing gene expression and miRNA profiling of I ex vivo i isolated human EOMES SP + sp Tr1-like cells, we provide additional evidence that Tr1-like cells are a unique T-cell subset. Keywords: Tr1-like cells; microRNAs; EOMES; IL-10R EN Tr1-like cells microRNAs EOMES IL-10R 3243 3246 4 12/17/21 20211201 NES 211201 Ex vivo gene expression and miRNA profiling of Eomes SP + sp Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4 SP + sp T-cells.
- Subjects
GENE expression profiling; REGULATORY T cells; MICRORNA
- Publication
European Journal of Immunology, 2021, Vol 51, Issue 12, p3243
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.202149315