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- Title
Diphenyl Ditelluride Intoxication Triggers Histological Changes in Liver, Kidney, and Lung of Mice.
- Authors
Almeida da Luz, Sônia Cristina; Falster Daubermann, Melissa; Thomé, Gustavo Roberto; Mülling dos Santos, Matheus; Ramos, Angelica; Torres Salazar, Gerson; Teixeira da Rocha, João Batista; Vargas Barbosa, Nilda
- Abstract
Tellurium compounds may be cytotoxic to different cells types. Thus, this work evaluated the effect of diphenyl ditelluride ((PhTe)2), an organotellurium commonly used in organic synthesis, on the morphology of liver, kidney, and lung. Adult mice were acutely (a subcutaneous single dose: 250 µmol/kg) or subchronically (one daily subcutaneous dose: 10 or 50 µmol/kg for 7 and 14 days) exposed to (PhTe)2. Afterwards, the histological analyses of liver, kidney, and lungs were performed. Liver histology revealed that the hepatocytes of mice subchronically exposed to (PhTe)2 presented cytoplasmic vacuolization, hydropic degeneration, and hyperchromatic nuclei. Subchronic exposure to 50 µmol/kg (PhTe)2 also caused hepatic necrosis.Microvesicular and macrovesicular steatosis were identified in liver of mice acutely exposed to (PhTe)2. Acute and subchronic intoxication with (PhTe)2 induced changes on epithelial cells of renal tubules, namely, loss of brush border and cytoplasmatic vacuolization. Atrophy and hypertrophy, cast proteinaceous formation, and acute tubular necrosis were also identified in renal tissue. Mice subchronically exposed to 50 µmol/kg (PhTe)2 developed intra-alveolar edema and alveolar wall congestion in some areas of lungs. Acute exposure to (PhTe)2 did not cause histological changes in lungs. Our data show that (PhTe)2 may be considered a histotoxic agent for liver, kidney, and lung.
- Subjects
TELLURIUM compounds; DIPHENYL; HISTOPATHOLOGY; NECROSIS; LUNG diseases
- Publication
Analytical Cellular Pathology: Cellular Oncology, 2015, Vol 2015, p1
- ISSN
2210-7177
- Publication type
Article
- DOI
10.1155/2015/784612