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- Title
Does vitamin C supplementation influence the levels of circulating oxidized LDL, sICAM-1, sVCAM-1 and vWF-antigen in healthy male smokers?
- Authors
Van Hoydonck, P G A; Schouten, E G; Manuel-y-Keenoy, B; van Campenhout, A; Hoppenbrouwers, K P M; Temme, E H M
- Abstract
OBJECTIVE:: To examine the effects of vitamin C supplementation on the concentration of oxidation markers, in particular, circulating oxidized LDL (OxLDL) and on endothelial activation markers. DESIGN:: Randomized double-blind, placebo-controlled crossover trial. SETTING:: Belgian population of the city of Leuven. SUBJECTS:: A total of 34 healthy male smokers aged 26-73?y. INTERVENTION:: Smokers were randomly assigned to receive either vitamin C (250?mg twice daily) or placebo capsules, each to be taken for 4 weeks. After a 1-week washout period, participants then crossed over to the alternative capsules for further 4 weeks. MEAN OUTCOME MEASURES:: Markers of oxidation (bilirubin, uric acid,a-tocopherol, retinol, malondialdehyde, circulating Oxidized LDL (OxLDL)) and markers of endothelial activation (sICAM-1, sVCAM-1, vWF-antigen) were analysed. RESULTS:: Plasma ascorbate concentrations significantly increased from 46.6±17.6 to 70.1±21.2?µmol/l after a 4-week treatment with 500?mg vitamin C per day. The other plasma antioxidants concentrations, including bilirubin, uric acid,a-tocopherol and retinol, were similar in both treatment periods. Vitamin C did not change plasma malondialdehyde and circulating OxLDL compared with placebo (vitamin C 0.73±0.25?mg/dl OxLDL; placebo 0.72±0.21?mg/dl OxLDL). After vitamin C supplementation, neither sICAM-1 and sVCAM-1 levels nor the concentration of vWF-antigen significantly differed from placebo condition. CONCLUSIONS:: Oral supplementation of vitamin C is not associated with changes in markers of oxidation or endothelial activation in healthy male smokers. SPONSORSHIP:: The Unilever Chair in Nutritional Epidemiology, University of Leuven, Belgium.European Journal of Clinical Nutrition (2004) 58, 1587-1593. doi:10.1038/sj.ejcn.1601990 Published online 5 May 2004
- Subjects
LOUVAIN (Belgium); BELGIUM; VITAMIN C; DIETARY supplements; OXIDATION; LOW density lipoproteins; ANTIGENS
- Publication
European Journal of Clinical Nutrition, 2004, Vol 58, Issue 12, p1587
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/sj.ejcn.1601990