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- Title
OPTIMAL PATHOGEN - DIRECTED THERAPY USING THE MALDI TOF IN PEDIATRICS.
- Authors
Ferguson-Paul, Kenice; Xinhua Yu; Bagga, Bindiya; Arnold, Sandra R.
- Abstract
Background: Our objective was to determine the effect of the MALDI TOF on time to optimal antimicrobial therapy in bloodstream infections (BSI) compared to conventional methods. Methods: We reviewed all positive blood cultures from February 2012- 2014. The control group (CG) had pathogen identification using conventional methods and the intervention group (IG) with MALDI-TOF. Results: There were 199 cultures (CG, n=121, IG, n=78). The median time to species identification (hours) for the CG was 48, interquartile range (IQR) 37-57 vs. IG=17, IQR 14-23 (median difference 31, 95% Confidence Interval (CI) -38 to -25). Median time to optimal therapy (hours) for the CG was 28, IQR 2-64 vs. IG= 14.5, IQR 3-55 (median difference -13.5, 95% CI -31-13). By Cox regression MALDI TOF was not associated with reduced time to optimal therapy (hazard ratio (HR) 1.2, p=0.64). Conclusions: Species level identification is faster with MALDI TOF in BSI but does not allow for faster time to optimal antimicrobials.
- Subjects
PATHOGENIC microorganisms; MATRIX-assisted laser desorption-ionization; ANTI-infective agents; CONFIDENCE intervals; TIME-of-flight spectrometry
- Publication
Pediatric Oncall Journal, 2018, Vol 15, Issue 4, p97
- ISSN
0973-0966
- Publication type
Article
- DOI
10.7199/ped.oncall.2018.38