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- Title
Management of noninfectious posterior uveitis with intravitreal drug therapy.
- Authors
Hui Yi Tan; Agrawal, Rupesh; Agarwal, Aniruddha; Lee, Cecilia S.; Chhablani, Jay; Gupta, Vishali; Khatri, Manoj; Nirmal, Jayabalan; Pavesio, Carlos
- Abstract
Uveitis is an important cause of vision loss worldwide due to its sight-threatening complications, especially cystoid macular edema, as well as choroidal neovascularization, macular ischemia, cataract, and glaucoma. Systemic corticosteroids are the mainstay of therapy for noninfectious posterior uveitis; however, various systemic side effects can occur. Intravitreal medication achieves a therapeutic level in the vitreous while minimizing systemic complications and is thus used as an exciting alternative. Corticosteroids, antivascular endothelial growth factors, immunomodulators such as methotrexate and sirolimus, and nonsteroidal anti-inflammatory drugs are currently available for intravitreal therapy. This article reviews the existing literature for efficacy and safety of these various options for intravitreal drug therapy for the management of noninfectious uveitis (mainly intermediate, posterior, and panuveitis).
- Subjects
UVEITIS; VISION disorders; NEOVASCULARIZATION; ADRENOCORTICAL hormones; METHOTREXATE; DISEASE risk factors
- Publication
Clinical Ophthalmology, 2016, Vol 10, p1983
- ISSN
1177-5467
- Publication type
Article
- DOI
10.2147/OPTH.S89341