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- Title
Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity.
- Authors
Nemerow, Glen R.; Stewart, Phoebe L.
- Abstract
Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules.
- Subjects
ADENOVIRUSES; INTEGRINS; GLYCOPROTEINS; CELL adhesion molecules; INFLAMMATORY mediators
- Publication
Viruses (1999-4915), 2016, Vol 8, Issue 12, p337
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v8120337