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- Title
Association Between Low Serum Testosterone and the Development of Metabolic Syndrome in Elderly Taiwanese Men.
- Authors
Zhong, Shang-Rong; Yang, Han-Hsuan; Liao, Cheng-Hsi; Yang, Deng-Ho; Tu, Shih-Kai; Hung, Chia-Lien; Liao, Chun-Cheng
- Abstract
Purpose: To assess the association between serum testosterone (T) and metabolic syndrome (MS) in different age groups in Taiwanese men. Materials and Methods: Male participants, regardless of age or any underlying disease, were identified from MJ Health Screening Center in Taiwan from 2007 to 2016 for this cross-sectional study. They were divided into three groups according to age, and further classified according to MS diagnosis. Basic patient characteristics with relevant parameters were obtained. One-way ANOVA of mean T values between different numbers of measures that exceeds the cut-off values of MS components was performed to assess the relationship of T and MS. Logistic regression analysis was also used to estimate the risk for MS with each increment in T, age, and BMI. Results: A total of 4,931 men were included. The MS group had significantly lower serum T levels compared to the non-MS group in each age group. The one-way ANOVA found the mean value of T was significantly higher in patients without MS component (6.19± 2.12 ng/mL) than those with 1– 5 MS components (with one MS component: 5.48± 2.13 ng/mL, two MS components: 4.93± 2.03 ng/mL, three MS components: 4.37± 1.60 ng/mL, four MS components: 4.13± 2.89 ng/mL, five MS components: 3.74± 1.27 ng/mL, and P< 0.001). There was no significant difference between the patients with three components and the patients with four or five components. Logistic regression models with age stratification showed T with lower odds ratio (OR) for MS after adjusting for BMI in those ≥ 65 years old (OR=0.693; 95% CI=0.559– 0.858; P< 0.001); 50– 64 years old (OR=0.868; 95% CI=0.802– 0.940; P< 0.001) and < 50 years old (OR=0.810; 95% CI=0.758– 0.865; P< 0.001). Conclusion: Lower serum T was strongly associated with MS, with the predictive value increasing with age in Taiwanese men.
- Subjects
TAIWAN; OLDER men; METABOLIC syndrome; AGE groups; LOGISTIC regression analysis; TESTOSTERONE
- Publication
Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2021, Vol 14, p99
- ISSN
1178-7007
- Publication type
Article
- DOI
10.2147/DMSO.S282832