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- Title
Does Apoptosis Play a Role in Varicella Zoster Virus Latency and Reactivation?
- Authors
James, Stephanie F.; Mahalingam, Ravi; Gilden, Don
- Abstract
Varicella zoster virus (VZV) is an exclusively human highly neurotropic alphaherpesvirus. To date, VZV has been shown to induce apoptosis, primarily through the intrinsic pathway in different cell types, except for neurons in which the virus becomes latent. This review summarizes current studies of varicella-induced apoptosis in non-neuronal cells. Future studies are proposed to determine whether apoptosis is terminated prematurely or even begins in neurons that are non-productively infected with VZV.
- Subjects
VARICELLA-zoster virus; APOPTOSIS; NERVOUS system; CHICKENPOX; NEURONS
- Publication
Viruses (1999-4915), 2012, Vol 4, Issue 9, p1509
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v4091509