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- Title
Early-mid treatment C-reactive protein level is a prognostic factor in aggressive non-Hodgkin’s lymphoma.
- Authors
Herishanu, Yair; Perry, Chava; Braunstein, Rony; Metser, Ur; Goor, Odelia; Rogowski, Ori; Berliner, Shlomo; Polliack, Aaron; Naparstek, Elizabeth
- Abstract
Background: In the light of an emerging role for early-mid treatment 18 F-deoxyfluoroglucose positron emission tomography (FDG-PET) as an important prognostic indicator in aggressive non-Hodgkin’s lymphoma (NHL) , we attempted to determine whether a simple parameter, such as the early-mid treatment CRP (C-reactive protein) level, could also be utilized as a significant prognostic factor in aggressive NHL. Patients and methods: Serum CRP levels were monitored in 55 patients with aggressive NHL. The lowest value of the early mid-term CRP levels recorded was compared with the interim PET-CT results, as well as with the clinical course and eventual outcome. Results: During chemotherapy, the lowest value of early-mid treatment CRP levels significantly predicted the results of the interim FDG-PET ( P = 0.04 with an odds ratio of 1.13). Patients who did not achieve an early-mid treatment CRP level of <5 mg/L, had a shorter time to disease progression or relapse ( P = 0.001) as well as a reduced overall survival (OS) ( P = 0.016). Conclusions: The early-mid treatment serum CRP level is a prognostic factor in aggressive NHL. Patients who do not achieve an early-mid treatment level of <5 mg/L have quicker disease progression or earlier relapse and also appear to have an inferior OS.
- Subjects
C-reactive protein; PROGNOSIS; LYMPHOMAS; POSITRON emission tomography; BLOOD plasma
- Publication
European Journal of Haematology, 2007, Vol 79, Issue 2, p150
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.1600-0609.2007.00894.x