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- Title
Myofibroblast-Derived SFRP1 as Potential Inhibitor of Colorectal Carcinoma Field Effect.
- Authors
Valcz, Gábor; Patai, Árpád V.; Kalmár, Alexandra; Péterfia, Bálint; Fűri, István; Wichmann, Barnabás; Műzes, Györgyi; Sipos, Ferenc; Krenács, Tibor; Mihály, Emese; Spisák, Sándor; Molnár, Béla; Tulassay, Zsolt
- Abstract
Epigenetic changes of stromal-epithelial interactions are of key importance in the regulation of colorectal carcinoma (CRC) cells and morphologically normal, but genetically and epigenetically altered epithelium in normal adjacent tumor (NAT) areas. Here we demonstrated retained protein expression of well-known Wnt inhibitor, secreted frizzled-related protein 1 (SFRP1) in stromal myofibroblasts and decreasing epithelial expression from NAT tissues towards the tumor. SFRP1 was unmethylated in laser microdissected myofibroblasts and partially hypermethylated in epithelial cells in these areas. In contrast, we found epigenetically silenced myofibroblast-derived SFRP1 in CRC stroma. Our results suggest that the myofibroblast-derived SFRP1 protein might be a paracrine inhibitor of epithelial proliferation in NAT areas and loss of this signal may support tumor proliferation in CRC.
- Subjects
MYOFIBROBLASTS; COLON cancer prevention; EPIGENETICS; EPITHELIAL cells; CELL communication; GENE expression
- Publication
PLoS ONE, 2014, Vol 9, Issue 11, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0106143