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- Title
Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT receptor function in adult rats.
- Authors
Matsuzaki, Hirokazu; Izumi, Takeshi; Horinouchi, Takahiro; Boku, Shuken; Inoue, Takeshi; Yamaguchi, Taku; Yoshida, Takayuki; Matsumoto, Machiko; Togashi, Hiroko; Miwa, Soichi; Koyama, Tsukasa; Yoshioka, Mitsuhiro
- Abstract
Rationale: Traumatic events in early life are associated with an increased risk of psychiatric diseases in adulthood. 5-hydroxytryptamine (5-HT) receptors play a pivotal role in the 5-HTergic mechanisms associated with the etiology of stress-related disorders. Objective: The goal of the present study was to investigate whether juvenile stress influences emotional control via postsynaptic 5-HT receptor in the hippocampus and amygdala using contextual fear conditioning test in adult rats. Methods: The rats were subjected to aversive footshock (FS) during the third week of the postnatal period (3wFS group). During the postadolescent period (10-14 weeks postnatal), experiments were performed. Results: The systemic administration of the 5-HT receptor agonist R-(+)-8-hydroxy-2-(di- n-propylamino) tetralin (8-OH-DPAT) (0.2 mg/kg, i.p.) attenuated the freezing behavior in the non-FS group, but not in the 3wFS group. The bilateral local injection of 8-OH-DPAT (1 μg/side) into the amygdala decreased the freezing behavior in the non-FS group and the 3wFS group. However, the local injection of 8-OH-DPAT (1 μg/side) into the hippocampus decreased the freezing behavior in the non-FS group, but not in the 3wFS group. In a 5-HT receptor binding study, the Bmax of the 3wFS group decreased in the dorsal hippocampus, but not the amygdala in comparison with the non-FS group. Conclusions: The juvenile stress attenuated the hippocampal postsynaptic 5-HT receptor function in context-dependent conditioned fear.
- Subjects
PSYCHOLOGICAL stress; HIPPOCAMPUS (Brain); NEURAL receptors; LABORATORY rats; CONTEXT effects (Psychology); FEAR
- Publication
Psychopharmacology, 2011, Vol 214, Issue 1, p329
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-010-1987-4