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- Title
The Price of "Humanization".
- Authors
Adissu, Hibret A.
- Abstract
Immunodeficient mice engrafted with functional human cells and tissues, also known as "humanized" mice, represent an innovative preclinical bridge for in vivo studies of human infectious disease, cancer, regenerative medicine, graft-versus-host disease, allergies, and immunity.[15] The NSG mouse (NOD.Cg I Prkdc SP scid sp Il2rg SP tm1Wjl sp i /SzJ) and less frequently the NRG (NOD.Cg I Rag1 SP tm1Mom sp Il2rg SP tm1Wjl sp / i SzJ) are commonly used to generate mice with a "humanized" immune system. The authors made 3 fascinating observations that were consistent with the predominance of myeloid-derived proliferations: histiocytic (granulomatous) lesions reminiscent of secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS), mast cell hyperplasia, and eosinophil hyperplasia. Mast cell hyperplasia, however, exhibited interesting peculiarities between naïve NSG-SGM mice and those engrafted with human cells with regard to the origin and distribution of mast cells. The basis and relevance of this preferential homing of mast cells to the pancreas and their disparate distribution between the naïve and manipulated NSG-SGM mice may signify a pathobiological significance yet to be discovered.
- Subjects
MULTINUCLEATED giant cells; CONNECTIVE tissue cells; T helper cells; FETAL liver cells; GRANULOCYTE-macrophage colony-stimulating factor; PHAGOCYTOSIS
- Publication
Veterinary Pathology, 2021, Vol 58, Issue 1, p7
- ISSN
0300-9858
- Publication type
Editorial
- DOI
10.1177/0300985820972995