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- Title
Susceptibility of Antimicrobial-Resistant Urinary Escherichia coli Isolates to Fluoroquinolones and Nitrofurantoin.
- Authors
Karlowsky, James A.; Thornsberry, Clyde; Jones, Mark E.; Sahm, Daniel F.
- Abstract
In vitro surveillance data from across the United States indicate that ∼10%-20% of urinary Escherichia coli isolates from female outpatients are resistant to trimethoprim-sulfamethoxazole (TMP-SMX). Alternative therapies for uncomplicated urinary tract infections in women include fluoroquinolones and nitrofurantoin, but the activities of these agents against TMP-SMX-resistant isolates are rarely reported. Among TMP-SMX-resistant urinary E. coli isolates tested in US laboratories from 1998 through 2001, 9.5% (5767 of 60,414) were resistant to ciprofloxacin and 1.9% (1214 of 63,817) were resistant to nitrofurantoin; 10.4% of ciprofloxacin-resistant isolates (683 of 6560) were resistant to nitrofurantoin. An association between resistance to fluor-oquinolones and nitrofurantoin in E. coli has not been previously reported and warrants further study.
- Subjects
UNITED States; ESCHERICHIA coli; ANTI-infective agents
- Publication
Clinical Infectious Diseases, 2003, Vol 36, Issue 2, p183
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/345754