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- Title
Cord blood fatty acid-binding protein-4 levels are upregulated at both ends of the birthweight spectrum.
- Authors
Papathanasiou, Aimilia Eirini; Briana, Despina D.; Gavrili, Stavroula; Georgantzi, Sophia; Papathoma, Evangelia; Marmarinos, Antonios; Christou, Christos; Voulgaris, Konstantinos; Gourgiotis, Dimitrios; Malamitsi‐Puchner, Ariadne; Malamitsi-Puchner, Ariadne
- Abstract
<bold>Aim: </bold>Fatty acid-binding protein-4 (FABP4) is an adipokine associated with obesity and signs of the metabolic syndrome. We aimed to investigate at birth in term neonates with normal and abnormal intrauterine growth concentrations of FABP4 and associate them with various perinatal parameters.<bold>Methods: </bold>Serum cord blood FABP4 levels were prospectively determined by ELISA in 80 singleton term appropriate-for-gestational-age (AGA), intrauterine growth-restricted (IUGR) and large-for-gestational-age (LGA) neonates.<bold>Results: </bold>Compared to the AGA group, cord blood FABP4 levels were increased in the IUGR and LGA groups. Additionally, they were higher in early-term than full-term neonates. A significant U-shaped correlation was recorded between serum FABP4 levels and birthweight. A significant negative correlation between cord blood FABP4 and gestational age in the whole study population was noted.<bold>Conclusion: </bold>Cord blood FABP4 levels were significantly higher at the extremes of foetal growth at term and negatively correlated with gestational age, being increased in early-term versus full-term neonates. Further longitudinal studies with larger sample sizes are required to elucidate FABP4 implication in foetal growth and its association with future adverse cardiometabolic outcomes in the offspring.
- Subjects
CORD blood; FETAL development; NEWBORN infants; SERUM; GESTATIONAL age; RETINOL-binding proteins; BIOCHEMISTRY; PHENOMENOLOGY; BIRTH weight; CARRIER proteins; LONGITUDINAL method
- Publication
Acta Paediatrica, 2019, Vol 108, Issue 11, p2083
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.14826