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- Title
Expression of CD105 but not of E-cadherin is associated with malignancy recurrence and disease-free interval in laryngeal cancer in men.
- Authors
Zvrko, Elvir; Vuckovic, Ljiljana
- Abstract
Introduction. In this study we analyzed CD105 (endoglin) and E-cadherin expression in laryngeal squamous cell carcinoma (LSCC) to evaluate their clinicopathologic significance. Material and methods. Expression of CD105 and E-cadherin was examined immunohistochemically using paraffin- -embedded archival tissues of 72 (35 glottic and 37 supraglottic) previously untreated LSCC male patients. The mean value of the positively-stained microvessels for CD105 counted in four hot spots for each case was used as the final intratumoralmicrovessel density (MVD). A staining score of E-cadherin was calculated based on the percentage of cells stained (0--100%). Results. MVD was significantly higher in patients with advanced TNM stage (P = 0.004) and younger than 65 (P = 0.008). Nodal metastases were more frequent in the cases with low E-cadherin expression (P = 0.000). Tumor recurrence was associated with advanced TNM stage (P = 0.035) and high MVD (P = 0.002). A high MVD was an independent predictor of malignancy recurrence (P = 0.021). The log-rank test showed a significant difference in the disease-free interval in patients stratified according to the MVD value (P = 0.016). Spearman's rank correlation test did not show a significant correlation between E-cadherin and CD105 expression. Conclusions. CD105-assessed MVD and expression of E-cadherin are promising prognostic factors for the outcome of patients with LSCC. Increased expression of CD105 could help predict patients with an increased risk of developing loco-regional recurrence after surgical treatment. Decreased E-cadherin expression is a potential predictor of lymph node metastases. (Folia Histochemica et Cytobiologica 2023, Vol. 61, No. 3, 183--192)
- Subjects
STATISTICS; GENETIC mutation; MEN'S health; NEOVASCULARIZATION inhibitors; IMMUNOHISTOCHEMISTRY; LOG-rank test; LARYNGEAL tumors; CANCER relapse; METASTASIS; RETROSPECTIVE studies; ENDOGLIN; GENE expression; TREATMENT effectiveness; GLYCOPROTEINS; DESCRIPTIVE statistics; TUMOR markers; DATA analysis; SQUAMOUS cell carcinoma; PARAFFIN wax
- Publication
Folia Histochemica et Cytobiologica, 2023, Vol 61, Issue 3, p183
- ISSN
0239-8508
- Publication type
Article
- DOI
10.5603/fhc.97035