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- Title
Inhibition of Spontaneous and Antibody- Dependent Cellular Cytotoxicity by Sera and Isolated Antiglobulin Preparations from Rheumatoid Arthritis Patients.
- Authors
Fink, P. C.; I. Schedel; Peter, H. H.; Deicher, H.
- Abstract
Using sera from patients with rheumatoid arthritis and antiglobulin preparations obtained from such sera, inhibition of human lymphocyte cytotoxicity in antibody- dependent (ADCC) and spontaneous cell-mediated cytotoxicity (SCMC) reactions against an allogeneic melanoma cell line (IGR3) has been demonstrated, Fractionation of effector ceil preparations indicated that Fc-receptor-bearing lymphocytes were operative in both reactions. Removal of phagocytit and adherent cells from the effector cell population resulted In more pronounced inhibition of SCMC and ADCC reactions by rheumatoid sera. The results indicate that antiglobulin preparations from human sera containing rheumatoid factor activity can effectively block the cytotoxic activity of Fc-receptor-bearing effector lymphocytes (K cells) in vitro. On analogy with the inhibition of ADCC and SCMC reactions by immune complexes and aggregated IgG, antiglobulin complexes present in the antiglobulin preparations are responsible for this effect.
- Subjects
CELL-mediated cytotoxicity; CELL death; KILLER cells; RHEUMATOID arthritis; COOMBS' test
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 3, p173
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb00382.x