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- Title
Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons.
- Authors
Tate, Simon; Benn, Susanna; Hick, Caroline; Trezise, Derek; John, Victoria; Mannion, Richard J.; Costigan, Michael; Plumpton, Chris; Grose, David; Gladwell, Zoe; Kendall, Giles; Dale, Katie; Bountra, Chas; Woolf, Clifford J.
- Abstract
We have cloned a second tetrodotoxin-resistant (TTX-R) sodium channel α subunit, SNS2, with the same amino-acid sequence as a putative sodium channel α subunit NaN (ref. 1). SNS2 expression in HEK293T cells produced a TTX-R voltage-gated sodium current with faster kinetics and a lower TTX IC50 than the previously cloned sensory-neuron-specific sodium channel, SNS/PN3 (Refs 2,3). SNS2 was co-expressed with SNS/PN3 in small DRG neurons.
- Subjects
SODIUM channels; SENSORY neurons
- Publication
Nature Neuroscience, 1998, Vol 1, Issue 8, p653
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/3652