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- Title
Biologic Differences Between Strains of Ebola Virus from Zaire and Sudan.
- Authors
McCormick, J. B.; Bauer, S. P.; Elliott, L. H.; Webb, P. A.; Johnson, K. M.
- Abstract
Studies of three outbreaks of Ebola hemorrhagic fever in Zaire and Sudan have shown that human mortality resulting from Zaire strains of Ebola virus was 90% while that resulting from Sudan strains was 55%–65%. Zaire strains were much easier to isolate in cell culture than all of the Sudanese agents; also, fewer than 10 infectious particles of a Zaire strain were lethal for suckling mice, whereas 10,000 infectious particles of a Sudan strain failed to kill any of these animals. These biologic data indicate that these antigenically related viruses are different, a conclusion supported by genetic, biochemical, and immunologic data.
- Publication
Journal of Infectious Diseases, 1983, Vol 147, Issue 2, p264
- ISSN
0022-1899
- Publication type
Article