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- Title
Lymphoplasmacytic lymphoma presenting cold agglutinin syndrome: Clonal expansion of KMT2D and IGHV4‐34 mutations after COVID‐19.
- Authors
Hayashi, Kiyohito; Koyama, Daisuke; Sato, Yuki; Fukatsu, Masahiko; Ikezoe, Takayuki
- Abstract
This article discusses a case of lymphoplasmacytic lymphoma (LPL) presenting as cold agglutinin syndrome (CAS) in a patient who had previously been infected with COVID-19. CAS is an autoimmune condition characterized by the presence of cold agglutinins, which are antibodies that cause the clumping of red blood cells. The patient in this case had elevated levels of IgM and exhibited symptoms such as visual field defects and haemolytic attacks. Whole-exome sequencing revealed the presence of a KMT2D mutation in the patient's bone marrow cells after COVID-19, suggesting clonal expansion of LPL cells. The study highlights the potential association between CAS and COVID-19, as well as the importance of considering molecular diagnosis and clonal evolution in the treatment of LPL with CAS.
- Subjects
BONE marrow cells; SCOTOMA; COVID-19; AGGLUTINATION; ERYTHROCYTES; WALDENSTROM'S macroglobulinemia; SYNDROMES
- Publication
British Journal of Haematology, 2023, Vol 203, Issue 5, pe110
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19106