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- Title
Clinical efficacy and safety of chimeric antigen receptor T‐cell therapy for mantle cell lymphoma with secondary central nervous system involvement.
- Authors
Ryan, Christine E.; Zon, Rebecca L.; Redd, Robert; Fisher, David C.; Shouval, Roni; Kumar, Anita; Crombie, Jennifer L.; Sadrzadeh, Hossein; Kim, Austin I.; Nayak, Lakshmi; Chukwueke, Ugonma N.; Jacobson, Caron A.; Frigault, Matthew J.; Palomba, M. Lia; Armand, Philippe; Epstein‐Peterson, Zachary; Merryman, Reid W.
- Abstract
Summary: Data describing outcomes of chimeric antigen receptor (CAR) T‐cell therapy in patients with secondary central nervous system (SCNS) involvement of mantle cell lymphoma (MCL) are limited. We identified 10 patients with MCL and SCNS involvement treated with anti‐CD19 CAR T‐cell therapy at three US academic centres. Frequent objective responses were observed in the CNS (86%) and systemically (90%), and the 1‐year progression‐free survival was 47%. Seven patients developed immune‐effector‐cell‐associated‐neurotoxicity‐syndrome (n = 2 Grade 1, n = 5 Grade 3). Our results suggest that anti‐CD19 CAR T‐cell therapy in this setting is feasible and additional data regarding neurotoxicity in this population may be warranted.
- Subjects
MANTLE cell lymphoma; CHIMERIC antigen receptors; CENTRAL nervous system; T cells; CELLULAR therapy
- Publication
British Journal of Haematology, 2023, Vol 203, Issue 5, p774
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.19037