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- Title
Impact of gender on outcomes of patients with multiple myeloma undergoing autologous Haematopoietic stem cell transplant.
- Authors
Pasvolsky, Oren; Saliba, Rima M.; Masood, Adeel; Mohamedi, Ali H.; Tanner, Mark R.; Bashir, Qaiser; Srour, Samer; Saini, Neeraj; Ramdial, Jeremy; Nieto, Yago; Lee, Hans C.; Patel, Krina K.; Kebriaei, Partow; Thomas, Sheeba K.; Weber, Donna M.; Orlowski, Robert Z.; Shpall, Elizabeth J.; Champlin, Richard E.; Qazilbash, Muzaffar H.
- Abstract
In the subset of patients aged >=50 ( I N i = 2293), most baseline characteristics were similar between the two genders, though more female patients had a lower performance score (KPS <= 80) at AHCT compared to males (43% vs. 38%; I p i = 0.01) (Table S2). Multiple myeloma (MM) is a common haematological malignancy, accounting for 1.8% of all new cases of cancer in the United States.[1] The prevalence of MM is slightly higher in men compared to women, 8.8 versus 5.7 new cases per 100 000 persons per year, respectively, yet the impact of gender on outcomes of patients with MM remains unclear, with contradictory reports in the literature.[[2], [4]] Specifically, the impact of gender on outcomes after high-dose chemotherapy and autologous haematopoietic stem cell transplantation (AHCT) has not been studied in detail. After a median follow-up among surviving patients of 53 (1-262) months, rates of disease progression were similar in both genders ([57%, 95% Confidence Interval (CI) 54-60] in females and [58%, 95% CI 55-61] in males; HR 0.9 [95% CI 0.9-1.1]; I p i = 0.7).
- Subjects
HEMATOPOIETIC stem cells; STEM cell transplantation; MULTIPLE myeloma; GENDER differences (Sociology); GENDER
- Publication
British Journal of Haematology, 2023, Vol 201, Issue 4, pe37
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18753