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- Title
Detection by a simple and cheaper methodology of Ik6 and Ik10 isoforms of the IKZF1 gene is highly associated with a poor prognosis in B‐lineage paediatric acute lymphoblastic leukaemia.
- Authors
Moreira, Larissa B. P.; Queiróz, Rosane de P.; Suazo, Veridiana K.; Perna, Elisabeth; Brandalise, Silvia R.; Yunes, José A.; Tone, Luiz G.; Scrideli, Carlos A.
- Abstract
Detection by a simple and cheaper methodology of Ik6 and Ik10 isoforms of the IKZF1 gene is highly associated with a poor prognosis in B-lineage paediatric acute lymphoblastic leukaemia The relative amounts of isoforms Ik6 and Ik10 were assessed by gel band densitometry using ImageJ software (ImageJ, US National Institutes of Health, Bethesda, MD, USA, https://imagej.nih.gov/ij/). The Ik6 or Ik10 isoforms were compared to full length isoforms of the I IKZF1 i gene by RT-PCR. High load negative I IKZF1 i isoforms were found in 12/99 patients (10 with the Ik6 isoform and 2 with Ik10).
- Subjects
LEUKEMIA; REVERSE transcriptase polymerase chain reaction
- Publication
British Journal of Haematology, 2019, Vol 187, Issue 3, pe58
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.16172