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- Title
Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion.
- Authors
Yano, Mio; Imamura, Toshihiko; Asai, Daisuke; Kiyokawa, Nobutaka; Nakabayashi, Kazuhiko; Matsumoto, Kenji; Deguchi, Takao; Hashii, Yoshiko; Honda, Yu‐ko; Hasegawa, Daiichiro; Sasahara, Yoji; Ishii, Mutsuo; Kosaka, Yoshiyuki; Kato, Koji; Shima, Midori; Hori, Hiroki; Yumura‐Yagi, Keiko; Hara, Junichi; Oda, Megumi; Horibe, Keizo
- Abstract
Activating tyrosine kinase mutations or cytokine receptor signalling alterations have attracted attention as therapeutic targets for high-risk paediatric acute lymphoblastic leukaemia (ALL). We identified two novel kinase fusions, OFD1-JAK2 and NCOR1-LYN, in paediatric ALL patients with IKZF1 deletion, by mRNA sequencing. The patient with CSF2RA-CRLF2 also harboured IGH-EPOR. All these patients had high-risk features, such as high initial white blood cell counts and initial poor response to prednisolone. The functional analysis of these novel fusions is on-going to determine whether these genetic alterations can be targeted by drugs.
- Subjects
LYMPHOBLASTIC leukemia treatment; CYTOKINE receptors; JANUS kinases; DELETION mutation; TARGETED drug delivery; BLOOD cell count
- Publication
British Journal of Haematology, 2015, Vol 171, Issue 5, p813
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.13757