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- Title
Novel N-Doped Carbon Dots/β-Cyclodextrin Nanocomposites for Enantioselective Recognition of Tryptophan Enantiomers.
- Authors
Qi Xiao; Shuangyan Lu; Chusheng Huang; Wei Su; Shan Huang
- Abstract
Based on N-doped carbon dots/β-cyclodextrin nanocomposites modified glassy carbon electrodes (N-CDs/β-CD/GCE), an effective electrochemical sensor for enantioselective recognition of tryptophan (Trp) enantiomers was developed by differential pulse voltammograms (DPVs). Fluorescent N-CDs were synthesized through a hydrothermal method and characterized by spectroscopic approaches. The N-CDs/β-CD nanocomposites were efficiently electrodeposited on the surface of GCE through C-N bond formation between N-CDs and electrode. The obtained N-CDs/β-CD/GCE was characterized by multispectroscopic and electrochemical methods. Such N-CDs/β-CD/GCE generated a significantly lower Ip and more negative Ep in the presence of L-Trp in DPVs, which was used for the enantioselective recognition of Trp enantiomers. The N-CDs/β-CD nanocomposites showed different binding constants for tryptophan enantiomers, and they further selectively bonded with L-Trp to form inclusion complexes. This N-CDs/β-CD/GCE combined advantages of N-CDs with strong C-N binding ability and β-CD with specific recognition of Trp enantiomers to fabricate a novel sensing platform for enantioselective recognition of Trp enantiomers. This strategy provided the possibility of using a nanostructured sensor to discriminate the chiral molecules in bio-electroanalytical applications.
- Subjects
CARBON electrodes; CYCLODEXTRINS; TRYPTOPHAN; DOPING agents (Chemistry); NANOCOMPOSITE materials; ENANTIOMERS analysis
- Publication
Sensors (14248220), 2016, Vol 16, Issue 11, p1874
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s16111874