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- Title
Effect of pronounced weight loss on the nontraditional cardiovascular risk marker matrix metalloproteinase-9 in middle-aged morbidly obese women.
- Authors
Laimer, M; Kaser, S; Kranebitter, M; Sandhofer, A; Mühlmann, G; Schwelberger, H; Weiss, H; Patsch, JR; Ebenbichler, CF
- Abstract
OBJECTIVE:: Obesity is associated with increased morbidity and mortality from atherosclerotic disease. Nontraditional cardiovascular risk factors such as C-reactive protein (CRP) and interleukin-6 (IL-6) are elevated in obese subjects and weight loss is associated with an attenuation of these risk factors. Matrix metalloproteinase-9 (MMP-9) has been linked to plaque rupture, and is, thus, a candidate marker of future myocardial events. The aim of this study was to determine the influence of weight loss on MMP-9 plasma concentrations. METHODS AND RESULTS:: CRP, IL-6 and MMP-9 were analyzed from samples of 45 morbidly obese, middle-aged women before gastric banding and 1?y postsurgical treatment in this prospective study. The body mass index (BMI) of subjects decreased from 42.5±4.9 to 32.3±5.3?kg/m2 1?y after gastric banding. In parallel, both MMP-9 and CRP were reduced by 23 and 41%, respectively. A positive relationship was found between BMI and MMP-9 (r=0.312, P<0.05), and between CRP and IL-6 (r=0.508, P<0.05), whereas no correlation was found between CRP and MMP-9. CONCLUSIONS:: We conclude that weight loss is associated with a pronounced decrease in the nontraditional cardiovascular risk markers MMP-9 and CRP, which could indicate future beneficial effects of weight loss on the cardiovascular risk in weight loosing subjects.International Journal of Obesity (2005) 29, 498-501. doi:10.1038/sj.ijo.0802897 Published online 1 February 2005
- Subjects
OBESITY; WEIGHT loss; ATHEROSCLEROSIS; DISEASES; MORTALITY; C-reactive protein
- Publication
International Journal of Obesity, 2005, Vol 29, Issue 5, p498
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0802897