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- Title
Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.
- Authors
Sklar, Pamela; Schwab, Sibylle G.; Williams, Nigel M.; Daly, Mark; Schaffner, Stephen; Maier, Wolfgang; Albus, Margot; Trixler, Matyas; Eichhammer, Peter; Lerer, Bernard; Hallmayer, Joachim; Norton, Nadine; Williams, Hywel; Zammit, Stan; Cardno, Alastair G.; Jones, Sue; McCarthy, Geraldine; Milanova, Vihra; Kirov, George
- Abstract
A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
- Subjects
GENETICS of schizophrenia; MEDICAL genetics
- Publication
Nature Genetics, 2001, Vol 28, Issue 2, p126
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/88836