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- Title
Population choice in mapping genes for complex diseases.
- Authors
Wright, Alan F; Carothers, Andrew D; Pirastu, Mario
- Abstract
The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions.
- Subjects
GENE mapping; MEDICAL genetics
- Publication
Nature Genetics, 1999, Vol 23, Issue 4, p397
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/70501