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- Title
Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones.
- Authors
Huang, Yafei; Cao, Shimin; Nagamani, Manubai; Anderson, Karl E; Grady, James J; Lu, Lee-Jane W
- Abstract
<bold>Context: </bold>TNF-alpha is a key mediator of inflammatory responses and may play a pivotal role in the development of cancer and in bone resorption.<bold>Objective: </bold>This study determined the effect of soy rich in isoflavones on levels of TNF-alpha.<bold>Design: </bold>Twelve postmenopausal women ingested a 36-oz portion of soymilk containing isoflavones daily for 16 wk and provided fasting blood samples multiple times before, during, and after soy consumption for the analyses of cytokines and monocyte content.<bold>Results: </bold>Compared with prediet levels (36.3 +/- 14.0 pg/ml), serum levels of TNF-alpha decreased by 25.1% (27.2 +/- 10.3 pg/ml; P < 0.01) as early as 2 wk after soy consumption and by 66.7% (11.6 +/- 5.3 pg/ml; P < 0.01) 10 wk after soy consumption and recovered to the prediet levels 4 wk after the termination of soy consumption (38.6 +/- 19.6 pg/ml; P = 0.66). A similar decrease of up to 56.6 and 14.4% was found for serum IL-1alpha and the mean percentage of blood monocytes during soy consumption, respectively, but not for IL-6. In cultures of monocytes or whole blood from postmenopausal women, soy isoflavones (genistein and daidzein, 10-1000 nm), tamoxifen (10-1000 nm), or 17beta-estradiol (0.1-10 nm) inhibited lipopolysaccharide (1 microg/ml)-induced TNF-alpha production by up to 55.8%.<bold>Conclusions: </bold>Isoflavones may be the active components in soy responsible for the decrease of TNF-alpha found in postmenopausal women during a soy diet. This antiinflammatory effect of the isoflavones may be important in immune modulation and the prevention of bone loss and cancer.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2005, Vol 90, Issue 7, p3956
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2005-0161