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- Title
Reduced IGFBP-1 is associated with thickening of the carotid wall in type 2 diabetes.
- Authors
Leinonen, Eeva S.; Taskinen, Marja-Riitta; Koistinen, Riitta A.; Leinonen, Pekka J.; Sarna, Seppo S.; Salonen, Riitta M.; Salonen, Jukka T.
- Abstract
<bold>Objective: </bold>The aim of the present study was to assess the role of the insulin-like growth factor (IGF) system and lipids in predicting the carotid intima-media thickness (IMT) in type 2 diabetes.<bold>Research Design and Methods: </bold>A total of 239 type 2 diabetic participants in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study (76 women) aged 50-75 years were examined before fenofibrate intervention. Patients underwent carotid ultrasonography for determination of IMT. IGF-I, IGF binding protein 1 (IGFBP-1), IGFBP-3, cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoprotein B (apoB), lipoprotein(a) (Lp(a)), glucose, HbA(1c), and C-peptide were measured in fasting samples. Patients were divided in groups without (n = 168) and with (n = 71) clinical cardiovascular disease (CVD).<bold>Results: </bold>Partial correlations adjusted for age, sex, BMI, and diabetes duration showed an inverse association of IGFBP-1 with C-peptide (r = -0. 24, P = 0.018) and with maximal IMT (r = -0.42, P < 0.001), whereas IGF I and IGFBP-3 correlated positively with several risk-promoting lipid parameters. In linear regression analysis controlling for age, sex, BMI, diabetes duration, and presence or absence of oral antihyperglycemic or insulin medication, determinants of IMT were age, IGFBP-1, pulse pressure, Lp(a), diabetes duration, and insulin treatment. IGFBP-1 persisted in the model for subjects with CVD.<bold>Conclusions: </bold>In summary, a decrease in IGFBP-1 is a marker of carotid IMT thickening in patients with type 2 diabetes.
- Subjects
FINLAND; HELSINKI (Finland); SOMATOMEDIN; LIPIDS; TYPE 2 diabetes
- Publication
Diabetes Care, 2002, Vol 25, Issue 10, p1807
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.25.10.1807