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- Title
Prognostic Value of EGFR and TGF-α in Early Laryngeal Cancer Treated With Radiotherapy.
- Authors
Wen, Qing-Hua; Miwa, Takaki; Yoshizaki, Tomokazu; Nagayama, Ikuo; Furukawa, Mitruru; Nishijima, Hiroshi
- Abstract
The purpose of this study was to determine the overexpression of both epidermal growth factor receptor (EGFR) and transforming growth factoralpha(TGF-α) (a ligand of EGFR) in early laryngeal squamous cell carcinoma. In addition, we attempted to evaluate the prognostic values of our findings. Expression of EGFR and TGF-α in tumor tissue was examined immunohistochemically in 68 patients who had been treated with radiotherapy for early laryngeal cancer. Overexpression of the two factors was noted in 42.6% and 55.9%, respectively. No significant differences due to age, tumor size, and location or grade of cancer tissues were seen. Higher survival rates, found in patients with EGFR (-) and TGF-α (-) tumors as compared with those with EGFR (+) and TGF-α (+) (97.4%, 100% and 86.2%, 86.8%, respectively), were not statistically significant. The recurrence rates were similar between EGFR (+) and EGFR (-) (37.9% and 35.9%, respectively). However, the recurrence rate in patients with TGF-α (+) was significantly higher (57.9%) than in those with TGF-α (-) (10%; P<.01). Therefore overexpression of TGF-α may be an important indicator for recurrence in patients with early laryngeal squamous cell carcinoma treated by irradiation. Laryngoscope, 106:884-885, 1996
- Publication
Laryngoscope, 1996, Vol 106, Issue 7, p884
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1097/00005537-199607000-00019