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- Title
Mycobacterium tuberculosis and the host macrophage: maintaining homeostasis or battling for survival?
- Authors
Kundu, Manikuntala; Basu, Joyoti
- Abstract
Mycobacterium tuberculosis is endowed with the ability to persist within its intracellular niche for years, often tilting the balance of the host-pathogen interaction in its favour. The host resists infection by releasing damaging free radicals, pushing the pathogen towards lysosomal degradation, releasing an arsenal of cytokines for triggering adaptive immunity and facilitating apoptosis for effective T cell antigen presentation. The bacterium counters these mechanisms and also metabolically reprograms the macrophage to its own benefit. Recent advances in these areas are reviewed here.
- Subjects
MYCOBACTERIUM tuberculosis; INTRACELLULAR pathogens; ECOLOGICAL niche; FREE radical pathophysiology; IMMUNITY; APOPTOSIS inducing factor
- Publication
Current Science (00113891), 2013, Vol 105, Issue 5, p617
- ISSN
0011-3891
- Publication type
Article