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Title
Method of the Year 2013.
Abstract
The article focuses on the impacts of DNA and RNA sequencing of single cells in several areas of biology and medicine. It highlights several advantages of singe-cell DNA sequencing including determination of mutation and structural changes in the genomes of cancer cells, description of clonal structure and accessibility of rare cells. Topics include challenges of scaling down single-cell sequencing and use of microfluidics and microwell technologies for high reproducibility of sequencing.