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- Title
Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule.
- Authors
Wan-Yu Lin; Yi Lu; Jui-Hsin Su; Zhi-Hong Wen; Chang-Feng Dai; Yao-Haur Kuo; Sheu, Jyh-Horng
- Abstract
Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.
- Subjects
ALCYONACEA; CORALS; CANCER cell growth; ANTI-inflammatory agents; SPECTROSCOPIC imaging; PREVENTION
- Publication
Marine Drugs, 2011, Vol 9, Issue 6, p994
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md9060994