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- Title
Molecular profiling of common fragile sites in human fibroblasts.
- Authors
Le Tallec, Benoî; Dutrillaux, Bernard; Lachages, Anne-Marie; Millot, Gael Armel; Brison, Olivier; Debatisse, Michelle
- Abstract
Common fragile sites have been mapped primarily in lymphocytes, but recent analyses show that the setting of these sites relies on cell type-dependent replication programs. Using a new approach, we molecularly mapped common fragile sites in human fibroblasts and showed that commitment to fragility depends on similar replication features in fibroblasts and lymphocytes, although different loci are committed in each cell type. Notably, the common fragile sites that we identified overlapped heretofore unexplained deletion clusters observed in tumors.
- Subjects
MOLECULAR biology; CONNECTIVE tissue cells; FIBROBLASTS; HUMAN beings; LEUCOCYTES; BLOOD cells
- Publication
Nature Structural & Molecular Biology, 2011, Vol 18, Issue 12, p1421
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2155