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- Title
The spike protein of SARS-CoV — a target for vaccine and therapeutic development.
- Authors
Lanying Du; Yuxian He; Yusen Zhou; Shuwen Liu; Bo-Jian Zheng; Shibo Jiang
- Abstract
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.
- Subjects
SARS disease; CORONAVIRUSES; T cell receptors; ANGIOTENSIN converting enzyme; VACCINES
- Publication
Nature Reviews Microbiology, 2009, Vol 7, Issue 3, p226
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2090