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- Title
Phenotypic variation in bacteria: the role of feedback regulation.
- Authors
Smits, Wiep Klaas; Kuipers, Oscar P.; Veening, Jan-Willem
- Abstract
To survive in rapidly changing environmental conditions, bacteria have evolved a diverse set of regulatory pathways that govern various adaptive responses. Recent research has reinforced the notion that bacteria use feedback-based circuitry to generate population heterogeneity in natural situations. Using artificial gene networks, it has been shown that a relatively simple 'wiring' of a bacterial genetic system can generate two or more stable subpopulations within an overall genetically homogeneous population. This review discusses the ubiquity of these processes throughout nature, as well as the presumed molecular mechanisms responsible for the heterogeneity observed in a selection of bacterial species.
- Subjects
BACTERIA classification; HETEROGENEITY; ESCHERICHIA coli; LAC operon; FUNGUS-bacterium relationships
- Publication
Nature Reviews Microbiology, 2006, Vol 4, Issue 4, p259
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro1381