We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
H-NS: a universal regulator for a dynamic genome.
- Authors
Dorman, Charles J.
- Abstract
The effect of the bacterial heat-stable nucleoid-structuring (H-NS) protein on gene expression is overwhelmingly negative and extends throughout the genome, pointing to an almost universal role for this nucleoid-associated protein as a transcriptional repressor. Its ability to exert widespread effects on gene expression probably reflects the fact that it binds to curved DNA, which is commonly found at promoters. H-NS and related proteins can engage in both homologous and heterologous protein–protein interactions. Recent data show that the genes that encode H-NS-like proteins can be carried on mobile genetic elements. This raises the possibility that horizontal gene transfer expands the repertoire of protein–protein interactions that nucleoid-associated proteins can engage in, with potentially profound consequences for the global gene-expression profile of the cell.
- Subjects
NUCLEOIDS; CELL nuclei; GENE expression; GENOMES; GENETIC repressors; MOLECULAR genetics; MICROBIOLOGY
- Publication
Nature Reviews Microbiology, 2004, Vol 2, Issue 5, p391
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro883