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- Title
Identify the role of Human Wharton's Jelly Mesenchymal Stem Cells in repairing injured uterine of rat.
- Authors
Wang, Hezhu; Yang, Xiaoqing; Chen, Xiaojing; Xie, Huihui; Wang, Junxia; Zhang, Yuquan
- Abstract
Aim: Maternal complications caused by the cesarean delivery inhibit the capability of preserving the uterus and subsequent fertility. However, successful restoration of the incisional scar continuously still remains a challenge. This work was to evaluate the repairing effect of Human Wharton's Jelly Mesenchymal Stem Cells (hWJ‐MSC) on incisional scar of the uterine. Methods: Eighteen rats were randomly assigned into two groups and nine for each: one group injected with hWJ‐MSC in phosphate buffer saline (PBS) and the other injected with PBS for comparison. Results: With hWJ‐MSC in PBS injected, the uterine endometrium and myometrium with full‐thickness injury were restored and the functionality was greatly improved in comparison with the group only with PBS injected. Conclusion: The hWJ‐MSC can repair the injured uterine effectively by promoting the uterine endometrium and myometrium cells proliferation and according to the chi‐square analysis the pregnancy is improved.
- Subjects
ENDOMETRIUM physiology; CELL proliferation; ANIMAL experimentation; ANIMALS; CHI-squared test; MYOMETRIUM; RATS; RESEARCH funding; STEM cells; UMBILICAL cord; IN vitro studies
- Publication
Journal of Obstetrics & Gynaecology Research, 2021, Vol 47, Issue 1, p320
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.14526