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- Title
Indium(III)-catalyzed Aza-Conia-Ene Reaction for the Synthesis of Indolizines.
- Authors
Meazza, Marta; Leth, Lars A.; Erickson, Jeremy D.; Jørgensen, Karl Anker
- Abstract
A new indium(III)-catalyzed reaction for the synthesis of a series of indolizine scaffolds has been developed. This methodology was highly efficient, allowing a low catalyst loading of 2 mol % (down to 0.5 mol %) and rendering the products in high yields through a 5- exo- dig aza-Conia-ene reaction. Furthermore, the possibility of incorporating an electrophile into the generated pyrrolidone ring in a one-pot synergistic fashion was demonstrated. Finally, based on experimental observations, a mechanism proposal was outlined.
- Subjects
INDIUM; ENE reactions; INDOLIZIDINES synthesis; ELECTROPHILES; PYRROLIDINONES
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 33, p7905
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201701820