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- Title
Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities.
- Authors
Yu-Sheng Shi; Yan Zhang; Wen-Zhong Hu; Xiu-Fu Zhang; Xin Fu; Xia Lv
- Abstract
Two new dihydrochalcone enantiomers (+)-1 and (-)-1, along with eight known compounds 3-10, were obtained from Pteris ensiformis. The planar structures were determined on the basis of extensive 1D and 2DNMR and HRESIMS. The resolution of (+)-1 and (-)-1 was achieved by chiral HPLC analysis. The absolute configurations of (+)-1 and (-)-1 were established by the bulkiness rule using Rh2(O2CCF3)4-induced circular dichroism (ICD) method. Compounds (+)-1, (-)-1, 8, 9 and 10 exhibited the inhibitory assay of NO production in mouse macrophages stimulated by LPS, with IC50 values of 2.0, 2.5, 8.0, 9.5 and 5.6 μM, respectively. Otherwise, compound 10 showed moderate cytotoxic activity against HCT-116, HepG-2 and BGC-823 cell lines with IC50 values of 3.0, 10.5 and 6.3 μM, respectively
- Subjects
DIHYDROCHALCONES; ENANTIOMERS analysis; PTERIS; DICHROISM; ANTINEOPLASTIC agents; NITRIC oxide
- Publication
Molecules, 2017, Vol 22, Issue 9, p1413
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22091413